“Drugs only work in people who take them,” was the incredibly perceptive statement from the multiple-former Surgeon General C. Everett Koop (1982-1989). A patient can’t derive benefit from the modern medicines we have in our armamentarium unless they actually take them. I would extend this statement to include that, “Drugs can only exert their effects properly if their dosage form and delivery technology are optimized.” For example, putting certain medications in oral solid dose may lead to their performance being almost totally useless if the therapeutic molecules […]